Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

Structural and functional studies of the ABL and EGFR kinase domains have recently suggested a common mechanism of activation by cancer-causing mutations. However, dynamics and mechanistic aspects of kinase activation by cancer mutations that stimulate conformational transitions and thermodynamic st...

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Detalles Bibliográficos
Autores principales: Dixit, Anshuman, Verkhivker, Gennady M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722018/
https://www.ncbi.nlm.nih.gov/pubmed/19714203
http://dx.doi.org/10.1371/journal.pcbi.1000487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722018/
https://www.ncbi.nlm.nih.gov/pubmed/19714203
http://dx.doi.org/10.1371/journal.pcbi.1000487

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