Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requires IKAROS function

B cell lineage acute lymphoblastic leukemia (ALL) arises in virtually all cases from B cell precursors that are arrested at pre–B cell receptor–dependent stages. The Philadelphia chromosome–positive (Ph(+)) subtype of ALL accounts for 25–30% of cases of adult ALL, has the most unfavorable clinical o...

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Detalles Bibliográficos
Autores principales: Trageser, Daniel, Iacobucci, Ilaria, Nahar, Rahul, Duy, Cihangir, von Levetzow, Gregor, Klemm, Lars, Park, Eugene, Schuh, Wolfgang, Gruber, Tanja, Herzog, Sebastian, Kim, Yong-mi, Hofmann, Wolf-Karsten, Li, Aihong, Storlazzi, Clelia Tiziana, Jäck, Hans-Martin, Groffen, John, Martinelli, Giovanni, Heisterkamp, Nora, Jumaa, Hassan, Müschen, Markus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722172/
https://www.ncbi.nlm.nih.gov/pubmed/19620627
http://dx.doi.org/10.1084/jem.20090004

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