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Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice
Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory fa...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722177/ https://www.ncbi.nlm.nih.gov/pubmed/19635865 http://dx.doi.org/10.1084/jem.20091507 |