Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

BACKGROUND: Missense mutations and multiplications of the α-synuclein gene cause autosomal dominant familial Parkinson's disease (PD). α-Synuclein protein is also a major component of Lewy bodies, the hallmark pathological inclusions of PD. Therefore, α-synuclein plays an important role in the...

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Detalles Bibliográficos
Autores principales: Daher, João Paulo L, Ying, Mingyao, Banerjee, Rebecca, McDonald, Rebecca S, Hahn, Myriam Dumas, Yang, Lichuan, Flint Beal, M, Thomas, Bobby, Dawson, Valina L, Dawson, Ted M, Moore, Darren J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722624/
https://www.ncbi.nlm.nih.gov/pubmed/19630976
http://dx.doi.org/10.1186/1750-1326-4-34

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