Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain

α-Synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is sufficient to cause early-onset, familial PD. A critical qu...

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Autores principales: Cronin, Kenneth D., Ge, Dongliang, Manninger, Paul, Linnertz, Colton, Rossoshek, Anna, Orrison, Bonnie M., Bernard, David J., El-Agnaf, Omar M.A., Schlossmacher, Michael G., Nussbaum, Robert L., Chiba-Falek, Ornit
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722989/
https://www.ncbi.nlm.nih.gov/pubmed/19498036
http://dx.doi.org/10.1093/hmg/ddp265

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