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Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA
Summary: Here, we present a method for estimating the frequencies of SNP alleles present within pooled samples of DNA using high-throughput short-read sequencing. The method was tested on real data from six strains of the highly monomorphic pathogen Salmonella Paratyphi A, sequenced individually and...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722999/ https://www.ncbi.nlm.nih.gov/pubmed/19497932 http://dx.doi.org/10.1093/bioinformatics/btp344 |