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Using temperature to analyze temporal dynamics in the songbird motor pathway

Many complex behaviors, like speech or music, have a hierarchical organization with structure on many timescales. How does the brain control the timing of behavioral sequences? Do different circuits control different timescales of the behavior? To address these questions, we use temperature to manip...

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Detalles Bibliográficos
Autores principales: Long, Michael A., Fee, Michale S.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723166/
https://www.ncbi.nlm.nih.gov/pubmed/19005546
http://dx.doi.org/10.1038/nature07448
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author Long, Michael A.
Fee, Michale S.
author_facet Long, Michael A.
Fee, Michale S.
author_sort Long, Michael A.
collection PubMed
description Many complex behaviors, like speech or music, have a hierarchical organization with structure on many timescales. How does the brain control the timing of behavioral sequences? Do different circuits control different timescales of the behavior? To address these questions, we use temperature to manipulate the biophysical dynamics in different regions of the songbird forebrain involved in song production. We found that cooling premotor nucleus HVC (proper name) slows song speed across all timescales by up to 45% while only slightly altering the acoustic structure, whereas cooling downstream motor nucleus RA (robust nucleus of the arcopallium) has no observable effect on song timing. Our observations suggest that dynamics within HVC are involved in the control of song timing, perhaps through a chain-like organization. Local manipulation of brain temperature should be broadly applicable to identify neural circuitry that controls the timing of behavioral sequences and, more generally, to study the origin and role of oscillatory and other forms of brain dynamics in neural systems.
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spelling pubmed-27231662009-08-07 Using temperature to analyze temporal dynamics in the songbird motor pathway Long, Michael A. Fee, Michale S. Nature Article Many complex behaviors, like speech or music, have a hierarchical organization with structure on many timescales. How does the brain control the timing of behavioral sequences? Do different circuits control different timescales of the behavior? To address these questions, we use temperature to manipulate the biophysical dynamics in different regions of the songbird forebrain involved in song production. We found that cooling premotor nucleus HVC (proper name) slows song speed across all timescales by up to 45% while only slightly altering the acoustic structure, whereas cooling downstream motor nucleus RA (robust nucleus of the arcopallium) has no observable effect on song timing. Our observations suggest that dynamics within HVC are involved in the control of song timing, perhaps through a chain-like organization. Local manipulation of brain temperature should be broadly applicable to identify neural circuitry that controls the timing of behavioral sequences and, more generally, to study the origin and role of oscillatory and other forms of brain dynamics in neural systems. 2008-11-13 /pmc/articles/PMC2723166/ /pubmed/19005546 http://dx.doi.org/10.1038/nature07448 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Long, Michael A.
Fee, Michale S.
Using temperature to analyze temporal dynamics in the songbird motor pathway
title Using temperature to analyze temporal dynamics in the songbird motor pathway
title_full Using temperature to analyze temporal dynamics in the songbird motor pathway
title_fullStr Using temperature to analyze temporal dynamics in the songbird motor pathway
title_full_unstemmed Using temperature to analyze temporal dynamics in the songbird motor pathway
title_short Using temperature to analyze temporal dynamics in the songbird motor pathway
title_sort using temperature to analyze temporal dynamics in the songbird motor pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723166/
https://www.ncbi.nlm.nih.gov/pubmed/19005546
http://dx.doi.org/10.1038/nature07448
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