Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells

The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find Ad5 serostatus does not predict Ad5-specific CD4(+) T-cell frequency, and no durable significant differences in...

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Autores principales: Hutnick, Natalie A., Carnathan, Diane G., Dubey, Sheri A., Cox, Kara, Kierstead, Lisa, Ratcliffe, Sarah J., Robertson, Michael N., Casimiro, Danilo R., Ertl, Hildegund C.J., Betts, Michael R.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723179/
https://www.ncbi.nlm.nih.gov/pubmed/19620962
http://dx.doi.org/10.1038/nm.1989
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author Hutnick, Natalie A.
Carnathan, Diane G.
Dubey, Sheri A.
Cox, Kara
Kierstead, Lisa
Ratcliffe, Sarah J.
Robertson, Michael N.
Casimiro, Danilo R.
Ertl, Hildegund C.J.
Betts, Michael R.
author_facet Hutnick, Natalie A.
Carnathan, Diane G.
Dubey, Sheri A.
Cox, Kara
Kierstead, Lisa
Ratcliffe, Sarah J.
Robertson, Michael N.
Casimiro, Danilo R.
Ertl, Hildegund C.J.
Betts, Michael R.
author_sort Hutnick, Natalie A.
collection PubMed
description The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find Ad5 serostatus does not predict Ad5-specific CD4(+) T-cell frequency, and no durable significant differences in Ad5-specific CD4(+) T-cells between Ad5-seropositive and seronegative subjects were observed following vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T-cells in increasing HIV-1 susceptibility in the STEP trial.
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spelling pubmed-27231792010-02-01 Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells Hutnick, Natalie A. Carnathan, Diane G. Dubey, Sheri A. Cox, Kara Kierstead, Lisa Ratcliffe, Sarah J. Robertson, Michael N. Casimiro, Danilo R. Ertl, Hildegund C.J. Betts, Michael R. Nat Med Article The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find Ad5 serostatus does not predict Ad5-specific CD4(+) T-cell frequency, and no durable significant differences in Ad5-specific CD4(+) T-cells between Ad5-seropositive and seronegative subjects were observed following vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T-cells in increasing HIV-1 susceptibility in the STEP trial. 2009-07-20 2009-08 /pmc/articles/PMC2723179/ /pubmed/19620962 http://dx.doi.org/10.1038/nm.1989 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hutnick, Natalie A.
Carnathan, Diane G.
Dubey, Sheri A.
Cox, Kara
Kierstead, Lisa
Ratcliffe, Sarah J.
Robertson, Michael N.
Casimiro, Danilo R.
Ertl, Hildegund C.J.
Betts, Michael R.
Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title_full Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title_fullStr Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title_full_unstemmed Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title_short Baseline Ad5 serostatus does not predict Ad5-HIV vaccine-induced expansion of Ad-specific CD4+ T-cells
title_sort baseline ad5 serostatus does not predict ad5-hiv vaccine-induced expansion of ad-specific cd4+ t-cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723179/
https://www.ncbi.nlm.nih.gov/pubmed/19620962
http://dx.doi.org/10.1038/nm.1989
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