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Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses

The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-...

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Detalles Bibliográficos
Autores principales: Yuseff, Maria-Isabel, Lankar, Danielle, Lennon-Duménil, Ana-Maria
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723867/
https://www.ncbi.nlm.nih.gov/pubmed/19416472
http://dx.doi.org/10.1111/j.1600-0854.2009.00913.x
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author Yuseff, Maria-Isabel
Lankar, Danielle
Lennon-Duménil, Ana-Maria
author_facet Yuseff, Maria-Isabel
Lankar, Danielle
Lennon-Duménil, Ana-Maria
author_sort Yuseff, Maria-Isabel
collection PubMed
description The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-bound Ags, while in T cells, it modulates the T cell response upon exposure to peptide-major histocompatibility complexes. In this review, we highlight the similarities that determine B and T cell activation, focusing on immune receptor downstream signaling events that lead to synapse formation. We stress the notion that polarization of T and B lymphocytes characterized by global changes in cytoskeleton and membrane trafficking modulates synapse structure and function, thus determining lymphocyte effector functions and fate.
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spelling pubmed-27238672009-08-14 Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses Yuseff, Maria-Isabel Lankar, Danielle Lennon-Duménil, Ana-Maria Traffic Review Articles The onset of an adaptive immune response requires the activation of T and B lymphocytes by antigen-presenting cells, through a specialized form of intercellular communication, known as the immunological synapse (IS). In B lymphocytes the IS promotes efficient recognition and acquisition of membrane-bound Ags, while in T cells, it modulates the T cell response upon exposure to peptide-major histocompatibility complexes. In this review, we highlight the similarities that determine B and T cell activation, focusing on immune receptor downstream signaling events that lead to synapse formation. We stress the notion that polarization of T and B lymphocytes characterized by global changes in cytoskeleton and membrane trafficking modulates synapse structure and function, thus determining lymphocyte effector functions and fate. Blackwell Publishing Ltd 2009-06 2009-04-22 /pmc/articles/PMC2723867/ /pubmed/19416472 http://dx.doi.org/10.1111/j.1600-0854.2009.00913.x Text en Journal compilation © 2009 Blackwell Munksgaard http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review Articles
Yuseff, Maria-Isabel
Lankar, Danielle
Lennon-Duménil, Ana-Maria
Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title_full Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title_fullStr Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title_full_unstemmed Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title_short Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses
title_sort dynamics of membrane trafficking downstream of b and t cell receptor engagement: impact on immune synapses
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723867/
https://www.ncbi.nlm.nih.gov/pubmed/19416472
http://dx.doi.org/10.1111/j.1600-0854.2009.00913.x
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