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A Combinatorial Approach to Detect Coevolved Amino Acid Networks in Protein Families of Variable Divergence
Communication between distant sites often defines the biological role of a protein: amino acid long-range interactions are as important in binding specificity, allosteric regulation and conformational change as residues directly contacting the substrate. The maintaining of functional and structural...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723916/ https://www.ncbi.nlm.nih.gov/pubmed/19730672 http://dx.doi.org/10.1371/journal.pcbi.1000488 |