Alternative Mechanisms for Tn5 Transposition

Bacterial transposons are known to move to new genomic sites using either a replicative or a conservative mechanism. The behavior of transposon Tn5 is anomalous. In vitro studies indicate that it uses a conservative mechanism while in vivo results point to a replicative mechanism. To explain this an...

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Detalles Bibliográficos
Autor principal: Ahmed, Asad
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723962/
https://www.ncbi.nlm.nih.gov/pubmed/19714209
http://dx.doi.org/10.1371/journal.pgen.1000619
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author Ahmed, Asad
author_facet Ahmed, Asad
author_sort Ahmed, Asad
collection PubMed
description Bacterial transposons are known to move to new genomic sites using either a replicative or a conservative mechanism. The behavior of transposon Tn5 is anomalous. In vitro studies indicate that it uses a conservative mechanism while in vivo results point to a replicative mechanism. To explain this anomaly, a model is presented in which the two mechanisms are not independent—as widely believed—but could represent alternate outcomes of a common transpositional pathway.
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spelling pubmed-27239622009-08-28 Alternative Mechanisms for Tn5 Transposition Ahmed, Asad PLoS Genet Review Bacterial transposons are known to move to new genomic sites using either a replicative or a conservative mechanism. The behavior of transposon Tn5 is anomalous. In vitro studies indicate that it uses a conservative mechanism while in vivo results point to a replicative mechanism. To explain this anomaly, a model is presented in which the two mechanisms are not independent—as widely believed—but could represent alternate outcomes of a common transpositional pathway. Public Library of Science 2009-08-28 /pmc/articles/PMC2723962/ /pubmed/19714209 http://dx.doi.org/10.1371/journal.pgen.1000619 Text en Asad Ahmed. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Ahmed, Asad
Alternative Mechanisms for Tn5 Transposition
title Alternative Mechanisms for Tn5 Transposition
title_full Alternative Mechanisms for Tn5 Transposition
title_fullStr Alternative Mechanisms for Tn5 Transposition
title_full_unstemmed Alternative Mechanisms for Tn5 Transposition
title_short Alternative Mechanisms for Tn5 Transposition
title_sort alternative mechanisms for tn5 transposition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723962/
https://www.ncbi.nlm.nih.gov/pubmed/19714209
http://dx.doi.org/10.1371/journal.pgen.1000619
work_keys_str_mv AT ahmedasad alternativemechanismsfortn5transposition

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