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Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region

Terminal deoxynucleotidyltransferase (Tdt) and DNA polymerase μ (pol μ) are two eukaryotic highly similar proteins involved in DNA processing and repair. Despite their high sequence identity, they differ widely in their activity: pol μ has a templated polymerase activity, whereas Tdt has a non-templ...

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Detalles Bibliográficos
Autores principales:	Romain, Félix, Barbosa, Isabelle, Gouge, Jérôme, Rougeon, François, Delarue, Marc
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724280/ https://www.ncbi.nlm.nih.gov/pubmed/19502493 http://dx.doi.org/10.1093/nar/gkp460

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