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The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation

In an effort to develop unnatural DNA base pairs we examined six pyridine-based nucleotides, d3MPy, d4MPy, d5MPy, d34DMPy, d35DMPy and d45DMPy. Each bears a pyridyl nucleobase scaffold but they are differentiated by methyl substitution, and were designed to vary both inter- and intra-strand packing...

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Detalles Bibliográficos
Autores principales:	Hwang, Gil Tae, Hari, Yoshiyuki, Romesberg, Floyd E.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Chemistry and Synthetic Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724283/ https://www.ncbi.nlm.nih.gov/pubmed/19515938 http://dx.doi.org/10.1093/nar/gkp467

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