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Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
Dysfunction of alsin, particularly its putative Rab5 guanine-nucleotide-exchange factor activity, has been linked to one form of juvenile onset recessive familial amyotrophic lateral sclerosis (ALS2). Multiple lines of alsin knockout (ALS2(-/-)) mice have been generated to model this disease. Howeve...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724476/ https://www.ncbi.nlm.nih.gov/pubmed/19630956 http://dx.doi.org/10.1186/1756-6606-2-23 |