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Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review

BACKGROUND: The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder. METHODS: A systematic Medline and repositories search concerning the usefulness of aripiprazole in bipolar disorder was performed, with the combination of t...

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Detalles Bibliográficos
Autores principales: Fountoulakis, Konstantinos N, Vieta, Eduard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724509/
https://www.ncbi.nlm.nih.gov/pubmed/19635147
http://dx.doi.org/10.1186/1744-859X-8-16
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author Fountoulakis, Konstantinos N
Vieta, Eduard
author_facet Fountoulakis, Konstantinos N
Vieta, Eduard
author_sort Fountoulakis, Konstantinos N
collection PubMed
description BACKGROUND: The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder. METHODS: A systematic Medline and repositories search concerning the usefulness of aripiprazole in bipolar disorder was performed, with the combination of the words 'aripiprazole' and 'bipolar'. RESULTS: The search returned 184 articles and was last updated on 15 April 2009. An additional search included repositories of clinical trials and previous systematic reviews specifically in order to trace unpublished trials. There were seven placebo-controlled randomised controlled trials (RCTs), six with comparator studies and one with add-on studies. They assessed the usefulness of aripiprazole in acute mania, acute bipolar depression and during the maintenance phase in comparison to placebo, lithium or haloperidol. CONCLUSION: Aripiprazole appears effective for the treatment and prophylaxis against mania. The data on bipolar depression are so far negative, however there is a need for further study at lower dosages. The most frequent adverse effects are extrapyramidal signs and symptoms, especially akathisia, without any significant weight gain, hyperprolactinaemia or laboratory test changes.
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spelling pubmed-27245092009-08-11 Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review Fountoulakis, Konstantinos N Vieta, Eduard Ann Gen Psychiatry Review BACKGROUND: The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder. METHODS: A systematic Medline and repositories search concerning the usefulness of aripiprazole in bipolar disorder was performed, with the combination of the words 'aripiprazole' and 'bipolar'. RESULTS: The search returned 184 articles and was last updated on 15 April 2009. An additional search included repositories of clinical trials and previous systematic reviews specifically in order to trace unpublished trials. There were seven placebo-controlled randomised controlled trials (RCTs), six with comparator studies and one with add-on studies. They assessed the usefulness of aripiprazole in acute mania, acute bipolar depression and during the maintenance phase in comparison to placebo, lithium or haloperidol. CONCLUSION: Aripiprazole appears effective for the treatment and prophylaxis against mania. The data on bipolar depression are so far negative, however there is a need for further study at lower dosages. The most frequent adverse effects are extrapyramidal signs and symptoms, especially akathisia, without any significant weight gain, hyperprolactinaemia or laboratory test changes. BioMed Central 2009-07-27 /pmc/articles/PMC2724509/ /pubmed/19635147 http://dx.doi.org/10.1186/1744-859X-8-16 Text en Copyright © 2009 Fountoulakis and Vieta; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fountoulakis, Konstantinos N
Vieta, Eduard
Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title_full Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title_fullStr Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title_full_unstemmed Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title_short Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
title_sort efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724509/
https://www.ncbi.nlm.nih.gov/pubmed/19635147
http://dx.doi.org/10.1186/1744-859X-8-16
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