Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups

Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene (TIRAP) have been associated with susceptibility and resistance to tuberculosis (TB) in a...

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Detalles Bibliográficos
Autores principales: Dissanayeke, Shobana Rebecca, Levin, Samuel, Pienaar, Sandra, Wood, Kathryn, Eley, Brian, Beatty, David, Henderson, Howard, Anderson, Suzanne, Levin, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724706/
https://www.ncbi.nlm.nih.gov/pubmed/19693265
http://dx.doi.org/10.1371/journal.pone.0006698

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