Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

BACKGROUND: Human African trypanosomiasis (HAT), a major parasitic disease spread in Africa, urgently needs novel targets and new efficacious chemotherapeutic agents. Recently, we discovered that 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine (compound 1) exhibits specific antitrypanosomal activi...

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Detalles Bibliográficos
Autores principales: Kuettel, Sabine, Mosimann, Marc, Mäser, Pascal, Kaiser, Marcel, Brun, Reto, Scapozza, Leonardo, Perozzo, Remo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724708/
https://www.ncbi.nlm.nih.gov/pubmed/19707572
http://dx.doi.org/10.1371/journal.pntd.0000506

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