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The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

BACKGROUND: The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population. METHODS: We selected 84 incident gastric cancer cases and 336 matched controls nested wi...

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Autores principales: Yang, Jae Jeong, Ko, Kwang-Pil, Cho, Lisa Y, Shin, Aesun, Gwack, Jin, Chang, Soung-Hoon, Shin, Hai-Rim, Yoo, Keun-Young, Kang, Daehee, Park, Sue K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725140/
https://www.ncbi.nlm.nih.gov/pubmed/19615068
http://dx.doi.org/10.1186/1471-2407-9-238
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author Yang, Jae Jeong
Ko, Kwang-Pil
Cho, Lisa Y
Shin, Aesun
Gwack, Jin
Chang, Soung-Hoon
Shin, Hai-Rim
Yoo, Keun-Young
Kang, Daehee
Park, Sue K
author_facet Yang, Jae Jeong
Ko, Kwang-Pil
Cho, Lisa Y
Shin, Aesun
Gwack, Jin
Chang, Soung-Hoon
Shin, Hai-Rim
Yoo, Keun-Young
Kang, Daehee
Park, Sue K
author_sort Yang, Jae Jeong
collection PubMed
description BACKGROUND: The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population. METHODS: We selected 84 incident gastric cancer cases and 336 matched controls nested within the Korean Multi-Center Cancer Cohort. Six SNPs on the TNF gene, TNF-α-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C, and TNF-β 252 A/G were genotyped. The ORs (95% CIs) were calculated using unconditional logistic regression model to detect each SNP and haplotype-pair effects for gastric cancer. The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. Multi dimensionality reduction (MDR) analyses were performed to explore the potential TNF gene-gene interactions. RESULTS: TNF-α-857 C/T containing the T allele was significantly associated with an increased risk of gastric cancer and a linear trend effect was observed in the additive model (OR = 1.6, 95% CI 1.0–2.5 for CT genotype; OR = 2.6, 95% CI 1.0–6.4 for TT genotype). All haplotype-pairs that contained TCT or CCC of TNF-α-1031 T/C, TNF-α-863 C/A, and TNF-α-857 C/T were associated with a significantly higher risk for gastric cancer only among smokers. In the MDR analysis, regardless of smoking status, TNF-α-857 C/T was included in the first list of SNPs with a significant main effect. CONCLUSION: TNF-α-857 C/T polymorphism may play an independent role in gastric carcinogenesis and the risk for gastric cancer by TNF genetic effect is pronounced by cigarette smoking.
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spelling pubmed-27251402009-08-12 The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study Yang, Jae Jeong Ko, Kwang-Pil Cho, Lisa Y Shin, Aesun Gwack, Jin Chang, Soung-Hoon Shin, Hai-Rim Yoo, Keun-Young Kang, Daehee Park, Sue K BMC Cancer Research Article BACKGROUND: The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population. METHODS: We selected 84 incident gastric cancer cases and 336 matched controls nested within the Korean Multi-Center Cancer Cohort. Six SNPs on the TNF gene, TNF-α-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C, and TNF-β 252 A/G were genotyped. The ORs (95% CIs) were calculated using unconditional logistic regression model to detect each SNP and haplotype-pair effects for gastric cancer. The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. Multi dimensionality reduction (MDR) analyses were performed to explore the potential TNF gene-gene interactions. RESULTS: TNF-α-857 C/T containing the T allele was significantly associated with an increased risk of gastric cancer and a linear trend effect was observed in the additive model (OR = 1.6, 95% CI 1.0–2.5 for CT genotype; OR = 2.6, 95% CI 1.0–6.4 for TT genotype). All haplotype-pairs that contained TCT or CCC of TNF-α-1031 T/C, TNF-α-863 C/A, and TNF-α-857 C/T were associated with a significantly higher risk for gastric cancer only among smokers. In the MDR analysis, regardless of smoking status, TNF-α-857 C/T was included in the first list of SNPs with a significant main effect. CONCLUSION: TNF-α-857 C/T polymorphism may play an independent role in gastric carcinogenesis and the risk for gastric cancer by TNF genetic effect is pronounced by cigarette smoking. BioMed Central 2009-07-17 /pmc/articles/PMC2725140/ /pubmed/19615068 http://dx.doi.org/10.1186/1471-2407-9-238 Text en Copyright ©2009 Yang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Jae Jeong
Ko, Kwang-Pil
Cho, Lisa Y
Shin, Aesun
Gwack, Jin
Chang, Soung-Hoon
Shin, Hai-Rim
Yoo, Keun-Young
Kang, Daehee
Park, Sue K
The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title_full The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title_fullStr The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title_full_unstemmed The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title_short The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
title_sort role of tnf genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725140/
https://www.ncbi.nlm.nih.gov/pubmed/19615068
http://dx.doi.org/10.1186/1471-2407-9-238
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