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Identification of a Domain which Affects Kinetics and Antagonistic Potency of Clozapine at 5-HT(3) Receptors

The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species. However, the structural requirements of the respective binding site for...

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Detalles Bibliográficos
Autores principales:	Rammes, Gerhard, Hosp, Christine, Eisensamer, Brigitte, Tanasic, Sascha, Nothdurfter, Caroline, Zieglgänsberger, Walter, Rupprecht, Rainer
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725292/ https://www.ncbi.nlm.nih.gov/pubmed/19696922 http://dx.doi.org/10.1371/journal.pone.0006715

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