Prevalence of G2P[4] and G12P[6] Rotavirus, Bangladesh

Approximately 20,000 stool specimens from patients with diarrhea visiting an urban and a rural hospital in Bangladesh during January 2001–May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (...

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Detalles Bibliográficos
Autores principales: Rahman, Mustafizur, Sultana, Rasheda, Ahmed, Giasuddin, Nahar, Sharifun, Hassan, Zahid M., Saiada, Farjana, Podder, Goutam, Faruque, Abu S. G., Siddique, A. K., Sack, David A., Matthijnssens, Jelle, Van Ranst, Marc, Azim, Tasnim
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725799/
https://www.ncbi.nlm.nih.gov/pubmed/17370511
http://dx.doi.org/10.3201/eid1301.060910
Descripción
Sumario:Approximately 20,000 stool specimens from patients with diarrhea visiting an urban and a rural hospital in Bangladesh during January 2001–May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (n = 471). During the 2001–2005 rotavirus seasons, G1P[8] (36.4%) and G9P[8] (27.7%) were the dominant strains, but G2[4] and G12P[6] were present in 15.4% and 3.1% of the rotavirus-positive patients, respectively. During the 2005–06 rotavirus season, G2P[4] (43.2%) appeared as the most prevalent strain, and G12P[6] became a more prevalent strain (11.1%) during this season. Because recently licensed rotavirus vaccines are specific for only P[8], these vaccines may not perform well in settings where non-P[8] types are prevalent.

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