Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin

The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, 1 where kdr is present at hi...

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Autores principales: N’Guessan, Raphael, Corbel, Vincent, Akogbéto, Martin, Rowland, Mark
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725864/
https://www.ncbi.nlm.nih.gov/pubmed/17479880
http://dx.doi.org/10.3201/eid1302.060631
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author N’Guessan, Raphael
Corbel, Vincent
Akogbéto, Martin
Rowland, Mark
author_facet N’Guessan, Raphael
Corbel, Vincent
Akogbéto, Martin
Rowland, Mark
author_sort N’Guessan, Raphael
collection PubMed
description The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, 1 where kdr is present at high frequency (Ladji), the other where An. gambiae is susceptible (Malanville). Holes were made in the nets to mimic worn nets. At Malanville, 96% of susceptible An. gambiae were inhibited from blood-feeding, whereas at Ladji feeding was uninhibited by ITNs. The mortality rate of An. gambiae in ITN huts was 98% in Malanville but only 30% at Ladji. The efficacy of IRS was equally compromised. Mosquitoes at Ladji had higher oxidase and esterase activity than a laboratory-susceptible strain, but this fact did not seem to contribute to resistance. Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin.
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spelling pubmed-27258642009-09-10 Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin N’Guessan, Raphael Corbel, Vincent Akogbéto, Martin Rowland, Mark Emerg Infect Dis Research The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, 1 where kdr is present at high frequency (Ladji), the other where An. gambiae is susceptible (Malanville). Holes were made in the nets to mimic worn nets. At Malanville, 96% of susceptible An. gambiae were inhibited from blood-feeding, whereas at Ladji feeding was uninhibited by ITNs. The mortality rate of An. gambiae in ITN huts was 98% in Malanville but only 30% at Ladji. The efficacy of IRS was equally compromised. Mosquitoes at Ladji had higher oxidase and esterase activity than a laboratory-susceptible strain, but this fact did not seem to contribute to resistance. Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin. Centers for Disease Control and Prevention 2007-02 /pmc/articles/PMC2725864/ /pubmed/17479880 http://dx.doi.org/10.3201/eid1302.060631 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
N’Guessan, Raphael
Corbel, Vincent
Akogbéto, Martin
Rowland, Mark
Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title_full Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title_fullStr Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title_full_unstemmed Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title_short Reduced Efficacy of Insecticide-treated Nets and Indoor Residual Spraying for Malaria Control in Pyrethroid Resistance Area, Benin
title_sort reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, benin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725864/
https://www.ncbi.nlm.nih.gov/pubmed/17479880
http://dx.doi.org/10.3201/eid1302.060631
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