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Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia

BACKGROUND: Excessive accumulation of bilirubin contributes to neonatal hyperbilirubinemia in rats. Heme oxygenase (HO) is one of the rate-limiting enzymes in catabolizing heme to bilirubin. In the present study, we investigated whether suppression of rat HO-1 (rHO-1) expression by small interferenc...

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Detalles Bibliográficos
Autores principales:	Wu, Jinyong, Su, Wen, Jin, Youxin, Shi, Yi, Li, Chune, Zhong, Wenwei, Zhang, Xuehong, Zhang, Zili, Xia, Zhenwei
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726144/ https://www.ncbi.nlm.nih.gov/pubmed/19646271 http://dx.doi.org/10.1186/1471-2199-10-77

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