The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients. In T-ALL lymphoblasts, we identified high frequency mutations in NOTCH1 (n=16), FBW7 (n=5) and P...

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Detalles Bibliográficos
Autores principales: Gedman, Amanda Larson, Chen, Qing, Desmoulin, Sita Kugel, Ge, Yubin, LaFiura, Katherine, Haska, Christina L., Cherian, Christina, Devidas, Meenakshi, Linda, Stephen B., Taub, Jeffrey W., Matherly, Larry H.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726275/
https://www.ncbi.nlm.nih.gov/pubmed/19340001
http://dx.doi.org/10.1038/leu.2009.64

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