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IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT
The International staging system (ISS) for multiple myeloma (MM) is a validated alternative to the Durie Salmon staging system (DSS) for predicting survival at diagnosis. We compared these staging systems for predicting outcomes after upfront autologous stem cell transplantation by analyzing the out...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726276/ https://www.ncbi.nlm.nih.gov/pubmed/19322205 http://dx.doi.org/10.1038/leu.2009.61 |
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author | Hari, Parameswaran N. Zhang, Mei-Jie Roy, Vivek Pérez, Waleska S Bashey, Asad To, Luen Bik Elfenbein, Gerald Freytes, Cesar O. Gale, Robert Peter Gibson, John Kyle, Robert A. Lazarus, Hillard M. McCarthy, Philip L. Milone, Gustavo A. Pavlovsky, Santiago Reece, Donna E. Schiller, Gary Vela-Ojeda, Jorge Weisdorf, Daniel Vesole, David |
author_facet | Hari, Parameswaran N. Zhang, Mei-Jie Roy, Vivek Pérez, Waleska S Bashey, Asad To, Luen Bik Elfenbein, Gerald Freytes, Cesar O. Gale, Robert Peter Gibson, John Kyle, Robert A. Lazarus, Hillard M. McCarthy, Philip L. Milone, Gustavo A. Pavlovsky, Santiago Reece, Donna E. Schiller, Gary Vela-Ojeda, Jorge Weisdorf, Daniel Vesole, David |
author_sort | Hari, Parameswaran N. |
collection | PubMed |
description | The International staging system (ISS) for multiple myeloma (MM) is a validated alternative to the Durie Salmon staging system (DSS) for predicting survival at diagnosis. We compared these staging systems for predicting outcomes after upfront autologous stem cell transplantation by analyzing the outcomes of 729 patients between 1995 and 2002. With a median follow-up of 56 months the univariate probabilities (95% CI) of non-relapse mortality (NRM), relapse, progression free (PFS) and overall survival (OS) at 5 years were 7%, 68%, 25% and 52%, respectively. The median overall survival for stages I, II, III by DSS and ISS were 82, 68, 50 and 64, 68, 45 months, respectively. The concordance between the two staging systems was only 36%. Staging systems were formally compared using Cox models fit with DSS and ISS stages. Relative risks of PFS and OS were significantly different for stages I vs. II and II vs. III for DSS but only for stages II vs. III for ISS. Although both systems were predictive of PFS and OS; the DSS was superior in formal statistical comparison using Brier Score. However, neither system was strongly predictive of outcomes indicating the need for newer schemes incorporating other prognostic markers. |
format | Text |
id | pubmed-2726276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-27262762010-02-01 IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT Hari, Parameswaran N. Zhang, Mei-Jie Roy, Vivek Pérez, Waleska S Bashey, Asad To, Luen Bik Elfenbein, Gerald Freytes, Cesar O. Gale, Robert Peter Gibson, John Kyle, Robert A. Lazarus, Hillard M. McCarthy, Philip L. Milone, Gustavo A. Pavlovsky, Santiago Reece, Donna E. Schiller, Gary Vela-Ojeda, Jorge Weisdorf, Daniel Vesole, David Leukemia Article The International staging system (ISS) for multiple myeloma (MM) is a validated alternative to the Durie Salmon staging system (DSS) for predicting survival at diagnosis. We compared these staging systems for predicting outcomes after upfront autologous stem cell transplantation by analyzing the outcomes of 729 patients between 1995 and 2002. With a median follow-up of 56 months the univariate probabilities (95% CI) of non-relapse mortality (NRM), relapse, progression free (PFS) and overall survival (OS) at 5 years were 7%, 68%, 25% and 52%, respectively. The median overall survival for stages I, II, III by DSS and ISS were 82, 68, 50 and 64, 68, 45 months, respectively. The concordance between the two staging systems was only 36%. Staging systems were formally compared using Cox models fit with DSS and ISS stages. Relative risks of PFS and OS were significantly different for stages I vs. II and II vs. III for DSS but only for stages II vs. III for ISS. Although both systems were predictive of PFS and OS; the DSS was superior in formal statistical comparison using Brier Score. However, neither system was strongly predictive of outcomes indicating the need for newer schemes incorporating other prognostic markers. 2009-03-26 2009-08 /pmc/articles/PMC2726276/ /pubmed/19322205 http://dx.doi.org/10.1038/leu.2009.61 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Hari, Parameswaran N. Zhang, Mei-Jie Roy, Vivek Pérez, Waleska S Bashey, Asad To, Luen Bik Elfenbein, Gerald Freytes, Cesar O. Gale, Robert Peter Gibson, John Kyle, Robert A. Lazarus, Hillard M. McCarthy, Philip L. Milone, Gustavo A. Pavlovsky, Santiago Reece, Donna E. Schiller, Gary Vela-Ojeda, Jorge Weisdorf, Daniel Vesole, David IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title | IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title_full | IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title_fullStr | IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title_full_unstemmed | IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title_short | IS THE INTERNATIONAL STAGING SYSTEM SUPERIOR TO THE DURIE SALMON STAGING SYSTEM? A COMPARISON IN MULTIPLE MYELOMA PATIENTS UNDERGOING AUTOLOGOUS TRANSPLANT |
title_sort | is the international staging system superior to the durie salmon staging system? a comparison in multiple myeloma patients undergoing autologous transplant |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726276/ https://www.ncbi.nlm.nih.gov/pubmed/19322205 http://dx.doi.org/10.1038/leu.2009.61 |
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