Structure and function of HCV IRES domains

The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this...

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Detalles Bibliográficos
Autor principal: Lukavsky, Peter J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726286/
https://www.ncbi.nlm.nih.gov/pubmed/18638512
http://dx.doi.org/10.1016/j.virusres.2008.06.004
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author Lukavsky, Peter J.
author_facet Lukavsky, Peter J.
author_sort Lukavsky, Peter J.
collection PubMed
description The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, I discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical, protein-based eukaryotic initiation factors.
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spelling pubmed-27262862009-08-18 Structure and function of HCV IRES domains Lukavsky, Peter J. Virus Res Article The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, I discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical, protein-based eukaryotic initiation factors. Elsevier Science 2009-02 /pmc/articles/PMC2726286/ /pubmed/18638512 http://dx.doi.org/10.1016/j.virusres.2008.06.004 Text en © 2009 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Lukavsky, Peter J.
Structure and function of HCV IRES domains
title Structure and function of HCV IRES domains
title_full Structure and function of HCV IRES domains
title_fullStr Structure and function of HCV IRES domains
title_full_unstemmed Structure and function of HCV IRES domains
title_short Structure and function of HCV IRES domains
title_sort structure and function of hcv ires domains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726286/
https://www.ncbi.nlm.nih.gov/pubmed/18638512
http://dx.doi.org/10.1016/j.virusres.2008.06.004
work_keys_str_mv AT lukavskypeterj structureandfunctionofhcviresdomains

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