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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE(2), IL-6, and IL-8 Production

Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA. Leptin is an adipokine regulating energy balance, and it has recently been related also to arthrit...

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Detalles Bibliográficos
Autores principales:	Vuolteenaho, Katriina, Koskinen, Anna, Kukkonen, Meiju, Nieminen, Riina, Päivärinta, Unto, Moilanen, Teemu, Moilanen, Eeva
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726438/ https://www.ncbi.nlm.nih.gov/pubmed/19688109 http://dx.doi.org/10.1155/2009/345838

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