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Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report

INTRODUCTION: We report a case of sinusoidal obstruction syndrome, a typical and life-threatening complication after allogeneic stem-cell transplantation, successfully treated with defibrotide despite massive multiple organ failure. CASE PRESENTATION: A 64-year-old Caucasian woman underwent allogene...

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Autores principales: Behre, Gerhard, Theurich, Sebastian, Christopeit, Maximilian, Weber, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726490/
https://www.ncbi.nlm.nih.gov/pubmed/19830097
http://dx.doi.org/10.4076/1752-1947-3-6164
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author Behre, Gerhard
Theurich, Sebastian
Christopeit, Maximilian
Weber, Thomas
author_facet Behre, Gerhard
Theurich, Sebastian
Christopeit, Maximilian
Weber, Thomas
author_sort Behre, Gerhard
collection PubMed
description INTRODUCTION: We report a case of sinusoidal obstruction syndrome, a typical and life-threatening complication after allogeneic stem-cell transplantation, successfully treated with defibrotide despite massive multiple organ failure. CASE PRESENTATION: A 64-year-old Caucasian woman underwent allogeneic peripheral blood stem-cell transplantation from her human leukocyte antigen-identical sister against aggressive lymphoplasmocytoid immunocytoma. Seven days later, the patient developed severe sinusoidal obstruction syndrome according to the modified Seattle criteria. We initiated treatment with defibrotide. Despite early treatment, multiple organ failure with kidney failure requiring dialysis and ventilator-dependent lung failure aggravated the clinical course. Furthermore, central nervous dysfunction occurred as well as transfusion refractory thrombocytopenia. CONCLUSION: As highlighted in our report, defibrotide is the most promising drug in the treatment of the formerly, almost lethal, severe sinusoidal obstruction syndrome to date. This is demonstrated very clearly in our patient. She improved completely, even after renal, cerebral and respiratory failure.
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spelling pubmed-27264902009-10-14 Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report Behre, Gerhard Theurich, Sebastian Christopeit, Maximilian Weber, Thomas J Med Case Reports Case report INTRODUCTION: We report a case of sinusoidal obstruction syndrome, a typical and life-threatening complication after allogeneic stem-cell transplantation, successfully treated with defibrotide despite massive multiple organ failure. CASE PRESENTATION: A 64-year-old Caucasian woman underwent allogeneic peripheral blood stem-cell transplantation from her human leukocyte antigen-identical sister against aggressive lymphoplasmocytoid immunocytoma. Seven days later, the patient developed severe sinusoidal obstruction syndrome according to the modified Seattle criteria. We initiated treatment with defibrotide. Despite early treatment, multiple organ failure with kidney failure requiring dialysis and ventilator-dependent lung failure aggravated the clinical course. Furthermore, central nervous dysfunction occurred as well as transfusion refractory thrombocytopenia. CONCLUSION: As highlighted in our report, defibrotide is the most promising drug in the treatment of the formerly, almost lethal, severe sinusoidal obstruction syndrome to date. This is demonstrated very clearly in our patient. She improved completely, even after renal, cerebral and respiratory failure. BioMed Central 2009-03-10 /pmc/articles/PMC2726490/ /pubmed/19830097 http://dx.doi.org/10.4076/1752-1947-3-6164 Text en Copyright ©2009 Behre et al; licensee Cases Network Ltd. licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Behre, Gerhard
Theurich, Sebastian
Christopeit, Maximilian
Weber, Thomas
Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title_full Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title_fullStr Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title_full_unstemmed Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title_short Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
title_sort successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726490/
https://www.ncbi.nlm.nih.gov/pubmed/19830097
http://dx.doi.org/10.4076/1752-1947-3-6164
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