Gliomatosis cerebri type II: two case reports

INTRODUCTION: Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. CASE PRESENTATION: Two patients, a 52-year-old man (Patient 1) and a...

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Detalles Bibliográficos
Autores principales: D’Urso, Pietro Ivo, D’Urso, Oscar Fernando, Marsigliante, Santo, Storelli, Carlo, Distante, Alessandro, Sanguedolce, Francesca, Cimmino, Antonia, Luzi, Giuseppe, Gianfreda, Cosimo Damiano, Montinaro, Antonio, Ciappetta, Pasqualino
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726545/
https://www.ncbi.nlm.nih.gov/pubmed/19830138
http://dx.doi.org/10.4076/1752-1947-3-7225
Descripción
Sumario:INTRODUCTION: Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. CASE PRESENTATION: Two patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization. CONCLUSION: Genes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy.

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