Cargando…
Gliomatosis cerebri type II: two case reports
INTRODUCTION: Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. CASE PRESENTATION: Two patients, a 52-year-old man (Patient 1) and a...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Cases Network Ltd
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726545/ https://www.ncbi.nlm.nih.gov/pubmed/19830138 http://dx.doi.org/10.4076/1752-1947-3-7225 |
_version_ | 1782170623178440704 |
---|---|
author | D’Urso, Pietro Ivo D’Urso, Oscar Fernando Marsigliante, Santo Storelli, Carlo Distante, Alessandro Sanguedolce, Francesca Cimmino, Antonia Luzi, Giuseppe Gianfreda, Cosimo Damiano Montinaro, Antonio Ciappetta, Pasqualino |
author_facet | D’Urso, Pietro Ivo D’Urso, Oscar Fernando Marsigliante, Santo Storelli, Carlo Distante, Alessandro Sanguedolce, Francesca Cimmino, Antonia Luzi, Giuseppe Gianfreda, Cosimo Damiano Montinaro, Antonio Ciappetta, Pasqualino |
author_sort | D’Urso, Pietro Ivo |
collection | PubMed |
description | INTRODUCTION: Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. CASE PRESENTATION: Two patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization. CONCLUSION: Genes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy. |
format | Text |
id | pubmed-2726545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Cases Network Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-27265452009-10-14 Gliomatosis cerebri type II: two case reports D’Urso, Pietro Ivo D’Urso, Oscar Fernando Marsigliante, Santo Storelli, Carlo Distante, Alessandro Sanguedolce, Francesca Cimmino, Antonia Luzi, Giuseppe Gianfreda, Cosimo Damiano Montinaro, Antonio Ciappetta, Pasqualino J Med Case Reports Case report INTRODUCTION: Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. CASE PRESENTATION: Two patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization. CONCLUSION: Genes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy. Cases Network Ltd 2009-06-15 /pmc/articles/PMC2726545/ /pubmed/19830138 http://dx.doi.org/10.4076/1752-1947-3-7225 Text en © 2009 D’Urso et al.; licensee Cases Network Ltd. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case report D’Urso, Pietro Ivo D’Urso, Oscar Fernando Marsigliante, Santo Storelli, Carlo Distante, Alessandro Sanguedolce, Francesca Cimmino, Antonia Luzi, Giuseppe Gianfreda, Cosimo Damiano Montinaro, Antonio Ciappetta, Pasqualino Gliomatosis cerebri type II: two case reports |
title | Gliomatosis cerebri type II: two case reports |
title_full | Gliomatosis cerebri type II: two case reports |
title_fullStr | Gliomatosis cerebri type II: two case reports |
title_full_unstemmed | Gliomatosis cerebri type II: two case reports |
title_short | Gliomatosis cerebri type II: two case reports |
title_sort | gliomatosis cerebri type ii: two case reports |
topic | Case report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726545/ https://www.ncbi.nlm.nih.gov/pubmed/19830138 http://dx.doi.org/10.4076/1752-1947-3-7225 |
work_keys_str_mv | AT dursopietroivo gliomatosiscerebritypeiitwocasereports AT dursooscarfernando gliomatosiscerebritypeiitwocasereports AT marsigliantesanto gliomatosiscerebritypeiitwocasereports AT storellicarlo gliomatosiscerebritypeiitwocasereports AT distantealessandro gliomatosiscerebritypeiitwocasereports AT sanguedolcefrancesca gliomatosiscerebritypeiitwocasereports AT cimminoantonia gliomatosiscerebritypeiitwocasereports AT luzigiuseppe gliomatosiscerebritypeiitwocasereports AT gianfredacosimodamiano gliomatosiscerebritypeiitwocasereports AT montinaroantonio gliomatosiscerebritypeiitwocasereports AT ciappettapasqualino gliomatosiscerebritypeiitwocasereports |