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Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse

BACKGROUND: Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that nanomaterials have the potential to affect human health. The purpose of this study was to investigate the effects of maternal exposu...

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Autores principales: Shimizu, Midori, Tainaka, Hitoshi, Oba, Taro, Mizuo, Keisuke, Umezawa, Masakazu, Takeda, Ken
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726979/
https://www.ncbi.nlm.nih.gov/pubmed/19640265
http://dx.doi.org/10.1186/1743-8977-6-20
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author Shimizu, Midori
Tainaka, Hitoshi
Oba, Taro
Mizuo, Keisuke
Umezawa, Masakazu
Takeda, Ken
author_facet Shimizu, Midori
Tainaka, Hitoshi
Oba, Taro
Mizuo, Keisuke
Umezawa, Masakazu
Takeda, Ken
author_sort Shimizu, Midori
collection PubMed
description BACKGROUND: Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that nanomaterials have the potential to affect human health. The purpose of this study was to investigate the effects of maternal exposure to nano-sized anatase titanium dioxide (TiO(2)) on gene expression in the brain during the developmental period using cDNA microarray analysis combined with Gene Ontology (GO) and Medical Subject Headings (MeSH) terms information. RESULTS: Analysis of gene expression using GO terms indicated that expression levels of genes associated with apoptosis were altered in the brain of newborn pups, and those associated with brain development were altered in early age. The genes associated with response to oxidative stress were changed in the brains of 2 and 3 weeks old mice. Changes of the expression of genes associated with neurotransmitters and psychiatric diseases were found using MeSH terms. CONCLUSION: Maternal exposure of mice to TiO(2 )nanoparticles may affect the expression of genes related to the development and function of the central nervous system.
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spelling pubmed-27269792009-08-14 Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse Shimizu, Midori Tainaka, Hitoshi Oba, Taro Mizuo, Keisuke Umezawa, Masakazu Takeda, Ken Part Fibre Toxicol Research BACKGROUND: Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that nanomaterials have the potential to affect human health. The purpose of this study was to investigate the effects of maternal exposure to nano-sized anatase titanium dioxide (TiO(2)) on gene expression in the brain during the developmental period using cDNA microarray analysis combined with Gene Ontology (GO) and Medical Subject Headings (MeSH) terms information. RESULTS: Analysis of gene expression using GO terms indicated that expression levels of genes associated with apoptosis were altered in the brain of newborn pups, and those associated with brain development were altered in early age. The genes associated with response to oxidative stress were changed in the brains of 2 and 3 weeks old mice. Changes of the expression of genes associated with neurotransmitters and psychiatric diseases were found using MeSH terms. CONCLUSION: Maternal exposure of mice to TiO(2 )nanoparticles may affect the expression of genes related to the development and function of the central nervous system. BioMed Central 2009-07-29 /pmc/articles/PMC2726979/ /pubmed/19640265 http://dx.doi.org/10.1186/1743-8977-6-20 Text en Copyright © 2009 Shimizu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Shimizu, Midori
Tainaka, Hitoshi
Oba, Taro
Mizuo, Keisuke
Umezawa, Masakazu
Takeda, Ken
Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title_full Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title_fullStr Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title_full_unstemmed Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title_short Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
title_sort maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726979/
https://www.ncbi.nlm.nih.gov/pubmed/19640265
http://dx.doi.org/10.1186/1743-8977-6-20
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