Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle

The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene re...

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Detalles Bibliográficos
Autores principales: Drace, Kevin, McLaughlin, Stephanie, Darby, Creg
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727005/
https://www.ncbi.nlm.nih.gov/pubmed/19707590
http://dx.doi.org/10.1371/journal.pone.0006741
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author Drace, Kevin
McLaughlin, Stephanie
Darby, Creg
author_facet Drace, Kevin
McLaughlin, Stephanie
Darby, Creg
author_sort Drace, Kevin
collection PubMed
description The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-β signaling pathway.
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spelling pubmed-27270052009-08-25 Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle Drace, Kevin McLaughlin, Stephanie Darby, Creg PLoS One Research Article The cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle of the worm, providing an assay for surface characteristics. A C. elegans gene required for biofilm attachment, bah-1, encodes a protein containing the domain of unknown function DUF23. The DUF23 domain is found in 61 predicted proteins in C. elegans, which can be divided into three distinct phylogenetic clades. bah-1 is expressed in seam cells, which are among the hypodermal cells that synthesize the cuticle, and is regulated by a TGF-β signaling pathway. Public Library of Science 2009-08-25 /pmc/articles/PMC2727005/ /pubmed/19707590 http://dx.doi.org/10.1371/journal.pone.0006741 Text en Drace et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Drace, Kevin
McLaughlin, Stephanie
Darby, Creg
Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title_full Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title_fullStr Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title_full_unstemmed Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title_short Caenorhabditis elegans BAH-1 Is a DUF23 Protein Expressed in Seam Cells and Required for Microbial Biofilm Binding to the Cuticle
title_sort caenorhabditis elegans bah-1 is a duf23 protein expressed in seam cells and required for microbial biofilm binding to the cuticle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727005/
https://www.ncbi.nlm.nih.gov/pubmed/19707590
http://dx.doi.org/10.1371/journal.pone.0006741
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AT darbycreg caenorhabditiselegansbah1isaduf23proteinexpressedinseamcellsandrequiredformicrobialbiofilmbindingtothecuticle

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