Synthesis and Conformational Analysis of Locked Carbocyclic Analogues of 1,3-Diazepinone Riboside, a High-Affinity Cytidine Deaminase Inhibitor

[Image: see text] Cytidine deaminase (CDA) catalyzes the deamination of cytidine via a hydrated transition-state intermediate that results from the nucleophilic attack of zinc-bound water at the active site. Nucleoside analogues where the leaving NH(3) group is replaced by a proton and prevent conve...

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Detalles Bibliográficos
Autores principales: Ludek, Olaf R., Schroeder, Gottfried K., Liao, Chenzhong, Russ, Pamela L., Wolfenden, Richard, Marquez, Victor E.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727169/
https://www.ncbi.nlm.nih.gov/pubmed/19618900
http://dx.doi.org/10.1021/jo901127a

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