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Proanthocyanidin to prevent formation of the reexpansion pulmonary edema

BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and the...

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Autores principales: Yucel, Orhan, Ucar, Ergun, Tozkoparan, Ergun, Gunal, Armagan, Akay, Cemal, Sahin, Mehmet Ali, Genc, Onur
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727506/
https://www.ncbi.nlm.nih.gov/pubmed/19638221
http://dx.doi.org/10.1186/1749-8090-4-40
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author Yucel, Orhan
Ucar, Ergun
Tozkoparan, Ergun
Gunal, Armagan
Akay, Cemal
Sahin, Mehmet Ali
Genc, Onur
author_facet Yucel, Orhan
Ucar, Ergun
Tozkoparan, Ergun
Gunal, Armagan
Akay, Cemal
Sahin, Mehmet Ali
Genc, Onur
author_sort Yucel, Orhan
collection PubMed
description BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects. RESULTS: In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue. CONCLUSION: PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE.
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spelling pubmed-27275062009-08-15 Proanthocyanidin to prevent formation of the reexpansion pulmonary edema Yucel, Orhan Ucar, Ergun Tozkoparan, Ergun Gunal, Armagan Akay, Cemal Sahin, Mehmet Ali Genc, Onur J Cardiothorac Surg Research Article BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects. RESULTS: In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue. CONCLUSION: PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE. BioMed Central 2009-07-28 /pmc/articles/PMC2727506/ /pubmed/19638221 http://dx.doi.org/10.1186/1749-8090-4-40 Text en Copyright © 2009 Yucel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yucel, Orhan
Ucar, Ergun
Tozkoparan, Ergun
Gunal, Armagan
Akay, Cemal
Sahin, Mehmet Ali
Genc, Onur
Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title_full Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title_fullStr Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title_full_unstemmed Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title_short Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
title_sort proanthocyanidin to prevent formation of the reexpansion pulmonary edema
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727506/
https://www.ncbi.nlm.nih.gov/pubmed/19638221
http://dx.doi.org/10.1186/1749-8090-4-40
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