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Proanthocyanidin to prevent formation of the reexpansion pulmonary edema
BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and the...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727506/ https://www.ncbi.nlm.nih.gov/pubmed/19638221 http://dx.doi.org/10.1186/1749-8090-4-40 |
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author | Yucel, Orhan Ucar, Ergun Tozkoparan, Ergun Gunal, Armagan Akay, Cemal Sahin, Mehmet Ali Genc, Onur |
author_facet | Yucel, Orhan Ucar, Ergun Tozkoparan, Ergun Gunal, Armagan Akay, Cemal Sahin, Mehmet Ali Genc, Onur |
author_sort | Yucel, Orhan |
collection | PubMed |
description | BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects. RESULTS: In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue. CONCLUSION: PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE. |
format | Text |
id | pubmed-2727506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27275062009-08-15 Proanthocyanidin to prevent formation of the reexpansion pulmonary edema Yucel, Orhan Ucar, Ergun Tozkoparan, Ergun Gunal, Armagan Akay, Cemal Sahin, Mehmet Ali Genc, Onur J Cardiothorac Surg Research Article BACKGROUND: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation. METHODS: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects. RESULTS: In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue. CONCLUSION: PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE. BioMed Central 2009-07-28 /pmc/articles/PMC2727506/ /pubmed/19638221 http://dx.doi.org/10.1186/1749-8090-4-40 Text en Copyright © 2009 Yucel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yucel, Orhan Ucar, Ergun Tozkoparan, Ergun Gunal, Armagan Akay, Cemal Sahin, Mehmet Ali Genc, Onur Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title | Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title_full | Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title_fullStr | Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title_full_unstemmed | Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title_short | Proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
title_sort | proanthocyanidin to prevent formation of the reexpansion pulmonary edema |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727506/ https://www.ncbi.nlm.nih.gov/pubmed/19638221 http://dx.doi.org/10.1186/1749-8090-4-40 |
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