The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia

Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no...

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Detalles Bibliográficos
Autores principales: Golombick, Terry, Diamond, Terry
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727780/
https://www.ncbi.nlm.nih.gov/pubmed/19707439
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author Golombick, Terry
Diamond, Terry
author_facet Golombick, Terry
Diamond, Terry
author_sort Golombick, Terry
collection PubMed
description Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”. Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.
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spelling pubmed-27277802009-08-25 The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia Golombick, Terry Diamond, Terry Biologics Brief Communication Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”. Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias. Dove Medical Press 2008-03 2008-03 /pmc/articles/PMC2727780/ /pubmed/19707439 Text en © 2008 Golombick and Diamond, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Brief Communication
Golombick, Terry
Diamond, Terry
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title_full The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title_fullStr The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title_full_unstemmed The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title_short The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
title_sort potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727780/
https://www.ncbi.nlm.nih.gov/pubmed/19707439
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