Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers

PURPOSE: This study evaluated mechanistic differences of pralatrexate, methotrexate, and pemetrexed. METHODS: Inhibition of dihydrofolate reductase (DHFR) was quantified using recombinant human DHFR. Cellular uptake and folylpolyglutamate synthetase (FPGS) activity were determined using radiolabeled...

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Detalles Bibliográficos
Autores principales: Izbicka, E., Diaz, A., Streeper, R., Wick, M., Campos, D., Steffen, R., Saunders, M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728224/
https://www.ncbi.nlm.nih.gov/pubmed/19221750
http://dx.doi.org/10.1007/s00280-009-0954-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728224/
https://www.ncbi.nlm.nih.gov/pubmed/19221750
http://dx.doi.org/10.1007/s00280-009-0954-4

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