The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains controversial. The indirect activation model suggests that they simply must neutralize all of the prosurvival Bcl-2 family members, whereas the direct...

Descripción completa

Detalles Bibliográficos
Autores principales: Mérino, Delphine, Giam, Maybelline, Hughes, Peter D., Siggs, Owen M., Heger, Klaus, O'Reilly, Lorraine A., Adams, Jerry M., Strasser, Andreas, Lee, Erinna F., Fairlie, Walter D., Bouillet, Philippe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728397/
https://www.ncbi.nlm.nih.gov/pubmed/19651893
http://dx.doi.org/10.1083/jcb.200905153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728397/
https://www.ncbi.nlm.nih.gov/pubmed/19651893
http://dx.doi.org/10.1083/jcb.200905153

Ejemplares similares