Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a transmembrane protein activated by protein misfolding in the ER. The cytoplasmic nuclease domain of Ire1 cleaves the messenger RNA (mRNA) encoding XBP-1 (X-box–binding protein 1), ena...

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Detalles Bibliográficos
Autores principales: Hollien, Julie, Lin, Jonathan H., Li, Han, Stevens, Nicole, Walter, Peter, Weissman, Jonathan S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728407/
https://www.ncbi.nlm.nih.gov/pubmed/19651891
http://dx.doi.org/10.1083/jcb.200903014

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