Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine

BACKGROUND: Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative treatment regimes in many nationa...

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Detalles Bibliográficos
Autores principales: Bacon, David J., Tang, Doug, Salas, Carola, Roncal, Norma, Lucas, Carmen, Gerena, Lucia, Tapia, Lorena, Llanos-Cuentas, A. Alejandro, Garcia, Coralith, Solari, Lelv, Kyle, Dennis, Magill, Alan J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728505/
https://www.ncbi.nlm.nih.gov/pubmed/19707564
http://dx.doi.org/10.1371/journal.pone.0006762

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