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Glyoxalase I Gene Deletion Mutants of Leishmania donovani Exhibit Reduced Methylglyoxal Detoxification

BACKGROUND: Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system. PRINCIPAL FINDINGS: Analysis of the L. donovani G...

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Detalles Bibliográficos
Autores principales:	Chauhan, Swati C., Madhubala, Rentala
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728510/ https://www.ncbi.nlm.nih.gov/pubmed/19710909 http://dx.doi.org/10.1371/journal.pone.0006805

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