Cargando…

Glyoxalase I Gene Deletion Mutants of Leishmania donovani Exhibit Reduced Methylglyoxal Detoxification

BACKGROUND: Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system. PRINCIPAL FINDINGS: Analysis of the L. donovani G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chauhan, Swati C., Madhubala, Rentala
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728510/ https://www.ncbi.nlm.nih.gov/pubmed/19710909 http://dx.doi.org/10.1371/journal.pone.0006805

Ejemplares similares

Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis
por: Anand, Sneha, et al.
Publicado: (2015)

Role of glyoxalase 1 in methylglyoxal detoxification–the broad player of psychiatric disorders
por: Toriumi, Kazuya, et al.
Publicado: (2021)

Characterization of Leishmania donovani Aquaporins Shows Presence of Subcellular Aquaporins Similar to Tonoplast Intrinsic Proteins of Plants
por: Biyani, Neha, et al.
Publicado: (2011)

PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function
por: Coukos, John S., et al.
Publicado: (2023)

The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity
por: Mittal, Nimisha, et al.
Publicado: (2017)

Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase Shows that It Is Indispensable for Parasite Growth and Infectivity
por: Chadha, Sanya, et al.
Publicado: (2017)

Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes
por: Anaya-Sanchez, Andrea, et al.
Publicado: (2021)

Paromomycin Affects Translation and Vesicle-Mediated Trafficking as Revealed by Proteomics of Paromomycin –Susceptible –Resistant Leishmania donovani
por: Chawla, Bhavna, et al.
Publicado: (2011)

Zn(2+) dependent glyoxalase I plays the major role in methylglyoxal detoxification and salinity stress tolerance in plants
por: Batth, Rituraj, et al.
Publicado: (2020)

Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification
por: Ghosh, Ajit, et al.
Publicado: (2016)

Epigenetic regulation of defense genes by histone deacetylase1 in human cell line-derived macrophages promotes intracellular survival of Leishmania donovani
por: Roy, Gargi, et al.
Publicado: (2020)

Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target
por: Chadha, Sanya, et al.
Publicado: (2018)

A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in Leishmania donovani
por: Chawla, Bhavna, et al.
Publicado: (2012)

Polymorphisms in Glyoxalase I Gene Are Not Associated with Glyoxalase I Expression in Whole Blood or Markers of Methylglyoxal Stress: The CODAM Study
por: Maasen, Kim, et al.
Publicado: (2021)

A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B
por: Bansal, Ruby, et al.
Publicado: (2019)

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage
por: Nigro, Cecilia, et al.
Publicado: (2017)

Inhibition of Methylglyoxal-Mediated Protein Modification in Glyoxalase I Overexpressing Mouse Lenses
por: Gangadhariah, Mahesha H., et al.
Publicado: (2010)

Arginine glycosylation enhances methylglyoxal detoxification
por: El Qaidi, Samir, et al.
Publicado: (2021)

Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major
por: Gowri, V S, et al.
Publicado: (2012)

Deletion of Glutamine Synthetase Gene Disrupts the Survivability and Infectivity of Leishmania donovani
por: Kumar, Vinay, et al.
Publicado: (2021)

Methylglyoxal metabolism in trypanosomes and leishmania
por: Wyllie, Susan, et al.
Publicado: (2011)

Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway
por: Chen, Yuan, et al.
Publicado: (2017)

Chromatin-Remodeling Factor BRG1 Is a Negative Modulator of L. donovani in IFNγ Stimulated and Infected THP-1 Cells
por: Brar, Harsimran Kaur, et al.
Publicado: (2022)

Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
por: Schumacher, Dagmar, et al.
Publicado: (2018)

Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes
por: Hansen, Fernanda, et al.
Publicado: (2017)

The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology
por: Schmoch, Thomas, et al.
Publicado: (2017)

Methylglyoxal improves zirconium stress tolerance in Raphanus sativus seedling shoots by restricting zirconium uptake, reducing oxidative damage, and upregulating glyoxalase I
por: Bless, Yoneal, et al.
Publicado: (2023)

The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania
por: Pawar, Harsh, et al.
Publicado: (2019)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1()
por: Lee, Der-Yen, et al.
Publicado: (2014)

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights
por: Distler, Margaret G., et al.
Publicado: (2012)

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
por: Sachdeva, Robin, et al.
Publicado: (2018)

Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo
por: Afrin, Farhat, et al.
Publicado: (2019)

Promastigotes of Leishmania donovani exhibited sensitivity towards the high altitudinal plant Cicer microphyllum
por: Keshav, Poonam, et al.
Publicado: (2021)

Characterization of Leishmania donovani MCM4: Expression Patterns and Interaction with PCNA
por: Minocha, Neha, et al.
Publicado: (2011)

Silencing of D-Lactate Dehydrogenase Impedes Glyoxalase System and Leads to Methylglyoxal Accumulation and Growth Inhibition in Rice
por: An, Baoguang, et al.
Publicado: (2017)

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal
por: Shishmarev, Dmitry, et al.
Publicado: (2018)

Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts
por: Stratmann, Bernd, et al.
Publicado: (2017)

Proteomic analysis of the secretome of Leishmania donovani
por: Silverman, J Maxwell, et al.
Publicado: (2008)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_m4652mnf4ulc1fs27re3qmn21s