Myopathy with Concurrent Tadalafil and Simvastatin

A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in m...

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Detalles Bibliográficos
Autores principales: Gargante, Maria Pia, Vacante, Marco, Russo, Cristina, Malaguarnera, Mariano
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728614/
https://www.ncbi.nlm.nih.gov/pubmed/19721707
http://dx.doi.org/10.1155/2009/378287
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author Gargante, Maria Pia
Vacante, Marco
Russo, Cristina
Malaguarnera, Mariano
author_facet Gargante, Maria Pia
Vacante, Marco
Russo, Cristina
Malaguarnera, Mariano
author_sort Gargante, Maria Pia
collection PubMed
description A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.
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spelling pubmed-27286142009-08-31 Myopathy with Concurrent Tadalafil and Simvastatin Gargante, Maria Pia Vacante, Marco Russo, Cristina Malaguarnera, Mariano Case Rep Med Case Report A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system. Hindawi Publishing Corporation 2009 2009-08-09 /pmc/articles/PMC2728614/ /pubmed/19721707 http://dx.doi.org/10.1155/2009/378287 Text en Copyright © 2009 Maria Pia Gargante et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gargante, Maria Pia
Vacante, Marco
Russo, Cristina
Malaguarnera, Mariano
Myopathy with Concurrent Tadalafil and Simvastatin
title Myopathy with Concurrent Tadalafil and Simvastatin
title_full Myopathy with Concurrent Tadalafil and Simvastatin
title_fullStr Myopathy with Concurrent Tadalafil and Simvastatin
title_full_unstemmed Myopathy with Concurrent Tadalafil and Simvastatin
title_short Myopathy with Concurrent Tadalafil and Simvastatin
title_sort myopathy with concurrent tadalafil and simvastatin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728614/
https://www.ncbi.nlm.nih.gov/pubmed/19721707
http://dx.doi.org/10.1155/2009/378287
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AT malaguarneramariano myopathywithconcurrenttadalafilandsimvastatin

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