In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes

Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosp...

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Autores principales: Sankiewicz, A., Gorodkiewicz, E., Figaszewski, Z.
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728757/
https://www.ncbi.nlm.nih.gov/pubmed/19696941
http://dx.doi.org/10.1080/15376510701623961
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author Sankiewicz, A.
Gorodkiewicz, E.
Figaszewski, Z.
author_facet Sankiewicz, A.
Gorodkiewicz, E.
Figaszewski, Z.
author_sort Sankiewicz, A.
collection PubMed
description Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylocholine (PC) were separated from erythrocyte ghosts and determined by HPLC. Blood samples from healthy adults were investigated. A very strong decrease in PC content in erythrocyte membranes due to lithium in vitro treatment was found, as well as a statistically significant increase in PI content.
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spelling pubmed-27287572009-08-19 In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes Sankiewicz, A. Gorodkiewicz, E. Figaszewski, Z. Toxicol Mech Methods Article Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylocholine (PC) were separated from erythrocyte ghosts and determined by HPLC. Blood samples from healthy adults were investigated. A very strong decrease in PC content in erythrocyte membranes due to lithium in vitro treatment was found, as well as a statistically significant increase in PI content. Informa Healthcare 2008-06-23 2008-07 /pmc/articles/PMC2728757/ /pubmed/19696941 http://dx.doi.org/10.1080/15376510701623961 Text en Copyright © Informa Healthcare USA, Inc. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Sankiewicz, A.
Gorodkiewicz, E.
Figaszewski, Z.
In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title_full In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title_fullStr In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title_full_unstemmed In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title_short In Vitro Interaction of Lithium on Phospholipids in Human Erythrocytes
title_sort in vitro interaction of lithium on phospholipids in human erythrocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728757/
https://www.ncbi.nlm.nih.gov/pubmed/19696941
http://dx.doi.org/10.1080/15376510701623961
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AT gorodkiewicze invitrointeractionoflithiumonphospholipidsinhumanerythrocytes
AT figaszewskiz invitrointeractionoflithiumonphospholipidsinhumanerythrocytes

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