GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues

β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were det...

Descripción completa

Detalles Bibliográficos
Autores principales: Jermacz, I., Maj, J., Morzycki, J. W., Wojtkielewicz, A.
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728759/
https://www.ncbi.nlm.nih.gov/pubmed/19696942
http://dx.doi.org/10.1080/15376510701623656
Descripción
Sumario:β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross—metathesis between β-carotene and functionalized alkenes.

Ejemplares similares