GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues

β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were det...

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Detalles Bibliográficos
Autores principales: Jermacz, I., Maj, J., Morzycki, J. W., Wojtkielewicz, A.
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728759/
https://www.ncbi.nlm.nih.gov/pubmed/19696942
http://dx.doi.org/10.1080/15376510701623656
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author Jermacz, I.
Maj, J.
Morzycki, J. W.
Wojtkielewicz, A.
author_facet Jermacz, I.
Maj, J.
Morzycki, J. W.
Wojtkielewicz, A.
author_sort Jermacz, I.
collection PubMed
description β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross—metathesis between β-carotene and functionalized alkenes.
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spelling pubmed-27287592009-08-19 GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues Jermacz, I. Maj, J. Morzycki, J. W. Wojtkielewicz, A. Toxicol Mech Methods Article β-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15′, C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross—metathesis between β-carotene and functionalized alkenes. Informa Healthcare 2008-06-23 2008-07 /pmc/articles/PMC2728759/ /pubmed/19696942 http://dx.doi.org/10.1080/15376510701623656 Text en Copyright © Informa Healthcare USA, Inc. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Jermacz, I.
Maj, J.
Morzycki, J. W.
Wojtkielewicz, A.
GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title_full GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title_fullStr GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title_full_unstemmed GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title_short GC-MS Analysis of β-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues
title_sort gc-ms analysis of β-carotene ethenolysis products and their synthesis as potentially active vitamin a analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728759/
https://www.ncbi.nlm.nih.gov/pubmed/19696942
http://dx.doi.org/10.1080/15376510701623656
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