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MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors

A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non‐coding RNA species that re...

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Autores principales: Nass, Dvora, Rosenwald, Shai, Meiri, Eti, Gilad, Shlomit, Tabibian‐Keissar, Hilla, Schlosberg, Anat, Kuker, Hagit, Sion‐Vardy, Netta, Tobar, Ana, Kharenko, Oleg, Sitbon, Einat, Lithwick Yanai, Gila, Elyakim, Eran, Cholakh, Hila, Gibori, Hadas, Spector, Yael, Bentwich, Zvi, Barshack, Iris, Rosenfeld, Nitzan
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728890/
https://www.ncbi.nlm.nih.gov/pubmed/18624795
http://dx.doi.org/10.1111/j.1750-3639.2008.00184.x
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author Nass, Dvora
Rosenwald, Shai
Meiri, Eti
Gilad, Shlomit
Tabibian‐Keissar, Hilla
Schlosberg, Anat
Kuker, Hagit
Sion‐Vardy, Netta
Tobar, Ana
Kharenko, Oleg
Sitbon, Einat
Lithwick Yanai, Gila
Elyakim, Eran
Cholakh, Hila
Gibori, Hadas
Spector, Yael
Bentwich, Zvi
Barshack, Iris
Rosenfeld, Nitzan
author_facet Nass, Dvora
Rosenwald, Shai
Meiri, Eti
Gilad, Shlomit
Tabibian‐Keissar, Hilla
Schlosberg, Anat
Kuker, Hagit
Sion‐Vardy, Netta
Tobar, Ana
Kharenko, Oleg
Sitbon, Einat
Lithwick Yanai, Gila
Elyakim, Eran
Cholakh, Hila
Gibori, Hadas
Spector, Yael
Bentwich, Zvi
Barshack, Iris
Rosenfeld, Nitzan
author_sort Nass, Dvora
collection PubMed
description A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non‐coding RNA species that regulate gene expression; many exhibit tissue‐specific expression and are misregulated in cancer. Using microRNA expression profiling, we found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are over‐expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain. By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy. These microRNAs thus represent excellent biomarkers for brain primary tumors. Previous reports have found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are expressed more strongly in developing neurons and brain than in adult brain. Thus, their specific over‐expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis.
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spelling pubmed-27288902009-08-27 MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors Nass, Dvora Rosenwald, Shai Meiri, Eti Gilad, Shlomit Tabibian‐Keissar, Hilla Schlosberg, Anat Kuker, Hagit Sion‐Vardy, Netta Tobar, Ana Kharenko, Oleg Sitbon, Einat Lithwick Yanai, Gila Elyakim, Eran Cholakh, Hila Gibori, Hadas Spector, Yael Bentwich, Zvi Barshack, Iris Rosenfeld, Nitzan Brain Pathol Research Articles A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain malignancies is essential for selection of proper treatment. MicroRNAs are a class of small non‐coding RNA species that regulate gene expression; many exhibit tissue‐specific expression and are misregulated in cancer. Using microRNA expression profiling, we found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are over‐expressed, specifically in brain primary tumors, as compared to primary tumors from other tissues and their metastases to the brain. By considering the expression of only these two microRNAs, it is possible to distinguish between primary and metastatic brain tumors with very high accuracy. These microRNAs thus represent excellent biomarkers for brain primary tumors. Previous reports have found that hsa‐miR‐92b and hsa‐miR‐9/hsa‐miR‐9* are expressed more strongly in developing neurons and brain than in adult brain. Thus, their specific over‐expression in brain primary tumors supports a functional role for these microRNAs or a link between neuronal stem cells and brain tumorigenesis. Blackwell Publishing Ltd 2008-07-08 /pmc/articles/PMC2728890/ /pubmed/18624795 http://dx.doi.org/10.1111/j.1750-3639.2008.00184.x Text en © 2008 Rosetta Genomics Ltd; © 2008 International Society of Neuropathology Open access.
spellingShingle Research Articles
Nass, Dvora
Rosenwald, Shai
Meiri, Eti
Gilad, Shlomit
Tabibian‐Keissar, Hilla
Schlosberg, Anat
Kuker, Hagit
Sion‐Vardy, Netta
Tobar, Ana
Kharenko, Oleg
Sitbon, Einat
Lithwick Yanai, Gila
Elyakim, Eran
Cholakh, Hila
Gibori, Hadas
Spector, Yael
Bentwich, Zvi
Barshack, Iris
Rosenfeld, Nitzan
MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title_full MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title_fullStr MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title_full_unstemmed MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title_short MiR‐92b and miR‐9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
title_sort mir‐92b and mir‐9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728890/
https://www.ncbi.nlm.nih.gov/pubmed/18624795
http://dx.doi.org/10.1111/j.1750-3639.2008.00184.x
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