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Biomolecular Markers in Cancer of the Tongue
The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerni...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728936/ https://www.ncbi.nlm.nih.gov/pubmed/19696947 http://dx.doi.org/10.1155/2009/412908 |
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author | Ferrari, Daris Codecà, Carla Fiore, Jessica Moneghini, Laura Bosari, Silvano Foa, Paolo |
author_facet | Ferrari, Daris Codecà, Carla Fiore, Jessica Moneghini, Laura Bosari, Silvano Foa, Paolo |
author_sort | Ferrari, Daris |
collection | PubMed |
description | The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis. |
format | Text |
id | pubmed-2728936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27289362009-08-20 Biomolecular Markers in Cancer of the Tongue Ferrari, Daris Codecà, Carla Fiore, Jessica Moneghini, Laura Bosari, Silvano Foa, Paolo J Oncol Review Article The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis. Hindawi Publishing Corporation 2009 2009-08-19 /pmc/articles/PMC2728936/ /pubmed/19696947 http://dx.doi.org/10.1155/2009/412908 Text en Copyright © 2009 Daris Ferrari et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ferrari, Daris Codecà, Carla Fiore, Jessica Moneghini, Laura Bosari, Silvano Foa, Paolo Biomolecular Markers in Cancer of the Tongue |
title | Biomolecular Markers in Cancer of the Tongue |
title_full | Biomolecular Markers in Cancer of the Tongue |
title_fullStr | Biomolecular Markers in Cancer of the Tongue |
title_full_unstemmed | Biomolecular Markers in Cancer of the Tongue |
title_short | Biomolecular Markers in Cancer of the Tongue |
title_sort | biomolecular markers in cancer of the tongue |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728936/ https://www.ncbi.nlm.nih.gov/pubmed/19696947 http://dx.doi.org/10.1155/2009/412908 |
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