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Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum

Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated...

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Autores principales: Zarineh, Alireza, Bulakhtina, Elena, Olson, Peter R., Silverman, Jan F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729294/
https://www.ncbi.nlm.nih.gov/pubmed/19718251
http://dx.doi.org/10.1155/2009/361212
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author Zarineh, Alireza
Bulakhtina, Elena
Olson, Peter R.
Silverman, Jan F.
author_facet Zarineh, Alireza
Bulakhtina, Elena
Olson, Peter R.
Silverman, Jan F.
author_sort Zarineh, Alireza
collection PubMed
description Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas.
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spelling pubmed-27292942009-08-28 Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum Zarineh, Alireza Bulakhtina, Elena Olson, Peter R. Silverman, Jan F. Case Rep Med Case Report Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas. Hindawi Publishing Corporation 2009 2009-06-02 /pmc/articles/PMC2729294/ /pubmed/19718251 http://dx.doi.org/10.1155/2009/361212 Text en Copyright © 2009 Alireza Zarineh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zarineh, Alireza
Bulakhtina, Elena
Olson, Peter R.
Silverman, Jan F.
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title_full Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title_fullStr Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title_full_unstemmed Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title_short Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
title_sort recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729294/
https://www.ncbi.nlm.nih.gov/pubmed/19718251
http://dx.doi.org/10.1155/2009/361212
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