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Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729294/ https://www.ncbi.nlm.nih.gov/pubmed/19718251 http://dx.doi.org/10.1155/2009/361212 |
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author | Zarineh, Alireza Bulakhtina, Elena Olson, Peter R. Silverman, Jan F. |
author_facet | Zarineh, Alireza Bulakhtina, Elena Olson, Peter R. Silverman, Jan F. |
author_sort | Zarineh, Alireza |
collection | PubMed |
description | Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas. |
format | Text |
id | pubmed-2729294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27292942009-08-28 Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum Zarineh, Alireza Bulakhtina, Elena Olson, Peter R. Silverman, Jan F. Case Rep Med Case Report Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas. Hindawi Publishing Corporation 2009 2009-06-02 /pmc/articles/PMC2729294/ /pubmed/19718251 http://dx.doi.org/10.1155/2009/361212 Text en Copyright © 2009 Alireza Zarineh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Zarineh, Alireza Bulakhtina, Elena Olson, Peter R. Silverman, Jan F. Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title | Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_full | Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_fullStr | Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_full_unstemmed | Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_short | Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_sort | recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729294/ https://www.ncbi.nlm.nih.gov/pubmed/19718251 http://dx.doi.org/10.1155/2009/361212 |
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