Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions

Several laboratories have reported the reprogramming of mouse and human fibroblasts into pluripotent cells, using retroviruses carrying the Oct4, Sox2, Klf4, and c-Myc transcription factor genes. In these experiments the frequency of reprogramming was lower than 0.1% of the infected cells, raising t...

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Detalles Bibliográficos
Autores principales: Varas, Florencio, Stadtfeld, Matthias, de Andres-Aguayo, Luisa, Maherali, Nimet, di Tullio, Alessandro, Pantano, Lorena, Notredame, Cedric, Hochedlinger, Konrad, Graf, Thomas
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2009
Materias:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729671/
https://www.ncbi.nlm.nih.gov/pubmed/19008347
http://dx.doi.org/10.1634/stemcells.2008-0696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729671/
https://www.ncbi.nlm.nih.gov/pubmed/19008347
http://dx.doi.org/10.1634/stemcells.2008-0696

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