Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist

Eltrombopag is a first-in-class, orally bioavailable, small-molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), which is being developed as a treatment for thrombocytopenia of various etiologies. In vitro studies have demonstrated that the activity of eltrombopag is dependent on expr...

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Detalles Bibliográficos
Autores principales: Erickson-Miller, Connie L, Delorme, Evelyne, Tian, Shin-Shay, Hopson, Christopher B, Landis, Amy J, Valoret, Elizabeth I, Sellers, Teresa S, Rosen, Jon, Miller, Stephen G, Luengo, Juan I, Duffy, Kevin J, Jenkins, Julian M
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729672/
https://www.ncbi.nlm.nih.gov/pubmed/19038790
http://dx.doi.org/10.1634/stemcells.2008-0366

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