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nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas

The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to compare with the clinicopathologic parameters. The expression of nm23-H1 protein was immunohi...

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Autores principales: Lee, Ju-Han, Cho, Su Jin, Zhang, Xianglan, Zheng, Zhenlong, Lee, Eung Seok, Kim, Aeree, Kim, Young-Sik, Chae, Yang-seok, Kim, Insun
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729885/
https://www.ncbi.nlm.nih.gov/pubmed/16891807
http://dx.doi.org/10.3346/jkms.2006.21.4.645
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author Lee, Ju-Han
Cho, Su Jin
Zhang, Xianglan
Zheng, Zhenlong
Lee, Eung Seok
Kim, Aeree
Kim, Young-Sik
Chae, Yang-seok
Kim, Insun
author_facet Lee, Ju-Han
Cho, Su Jin
Zhang, Xianglan
Zheng, Zhenlong
Lee, Eung Seok
Kim, Aeree
Kim, Young-Sik
Chae, Yang-seok
Kim, Insun
author_sort Lee, Ju-Han
collection PubMed
description The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to compare with the clinicopathologic parameters. The expression of nm23-H1 protein was immunohistochemically examined in 150 cases of non-Hodgkin's lymphomas; 85 diffuse large B cell lymphomas (DLBCL), 18 marginal zone B cell lymphomas (MZL), 3 mantle cell lymphomas, 25 peripheral T cell lymphomas, not otherwise specified (TCLNOS), and 19 NK/T cell lymphomas (NK/T). Eighty-one cases (58 DLBCL, 6 MZL, 4 TCLNOS, and 13 NK/T) were studied for nm23-H1 gene mutation in exon 1 to 5. The high expression of nm23-H1 protein was associated with the high IPI score (p=0.019) and the low survival rate of the patients (p=0.0039). The gene mutation of nm23-H1 was detected in 10.3% of DLBCL and 30.7% of NK/T; but none in MZL and TCLNOS. The mutation was found in exon 1 in 5 cases, exon 2 in two cases, exon 4 in one case and both exon 1 and 2 in two cases. Our results suggest that the expression of nm23-H1 protein can be used as a poor prognostic marker in non-Hodgkin's lymphomas, and the mutational change of gene may operate in the lymphomagenesis.
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spelling pubmed-27298852009-08-24 nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas Lee, Ju-Han Cho, Su Jin Zhang, Xianglan Zheng, Zhenlong Lee, Eung Seok Kim, Aeree Kim, Young-Sik Chae, Yang-seok Kim, Insun J Korean Med Sci Original Article The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to compare with the clinicopathologic parameters. The expression of nm23-H1 protein was immunohistochemically examined in 150 cases of non-Hodgkin's lymphomas; 85 diffuse large B cell lymphomas (DLBCL), 18 marginal zone B cell lymphomas (MZL), 3 mantle cell lymphomas, 25 peripheral T cell lymphomas, not otherwise specified (TCLNOS), and 19 NK/T cell lymphomas (NK/T). Eighty-one cases (58 DLBCL, 6 MZL, 4 TCLNOS, and 13 NK/T) were studied for nm23-H1 gene mutation in exon 1 to 5. The high expression of nm23-H1 protein was associated with the high IPI score (p=0.019) and the low survival rate of the patients (p=0.0039). The gene mutation of nm23-H1 was detected in 10.3% of DLBCL and 30.7% of NK/T; but none in MZL and TCLNOS. The mutation was found in exon 1 in 5 cases, exon 2 in two cases, exon 4 in one case and both exon 1 and 2 in two cases. Our results suggest that the expression of nm23-H1 protein can be used as a poor prognostic marker in non-Hodgkin's lymphomas, and the mutational change of gene may operate in the lymphomagenesis. The Korean Academy of Medical Sciences 2006-08 2006-08-22 /pmc/articles/PMC2729885/ /pubmed/16891807 http://dx.doi.org/10.3346/jkms.2006.21.4.645 Text en Copyright © 2006 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Ju-Han
Cho, Su Jin
Zhang, Xianglan
Zheng, Zhenlong
Lee, Eung Seok
Kim, Aeree
Kim, Young-Sik
Chae, Yang-seok
Kim, Insun
nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title_full nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title_fullStr nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title_full_unstemmed nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title_short nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas
title_sort nm23-h1 protein expression and gene mutation in 150 patients with non-hodgkin's lymphomas
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729885/
https://www.ncbi.nlm.nih.gov/pubmed/16891807
http://dx.doi.org/10.3346/jkms.2006.21.4.645
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