Cargando…

LRP1 Controls cPLA(2) Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export

BACKGROUND: ATP-binding cassette transporter A1 mediates apolipoprotein AI-dependent efflux of cholesterol and thereby removes cholesterol from peripheral tissues. ABCA1 expression is tightly regulated and deficiency of this cholesterol transporter results in cholesterol accumulation within cells. L...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Li, Choi, Hong Y., Li, Wei-Ping, Xu, Fang, Herz, Joachim
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729921/ https://www.ncbi.nlm.nih.gov/pubmed/19718435 http://dx.doi.org/10.1371/journal.pone.0006853

Ejemplares similares

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA(2) phosphorylation and translocation
por: Evans, John H, et al.
Publicado: (2002)

cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes
por: Cai, Bishuang, et al.
Publicado: (2012)

Novel role of cPLA(2)α in membrane and actin dynamics
por: Moes, Maarten, et al.
Publicado: (2010)

Role of Prednisolone in Platelet Activation by Inhibiting TxA(2) Generation through the Regulation of cPLA(2) Phosphorylation
por: Kim, Sanggu, et al.
Publicado: (2023)

HIV hijacks cholesterol transporter ABCA1 to get access to cellular cholesterol
por: Bukrinsky, Michael, et al.
Publicado: (2009)

cPLA(2)α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation
por: Ashcroft, Felicity J., et al.
Publicado: (2020)

Involvement of the γ Isoform of cPLA(2) in the Biosynthesis of Bioactive N-Acylethanolamines
por: Guo, Yiman, et al.
Publicado: (2021)

Phosphorylation of cPLA(2)α at Ser(505) Is Necessary for Its Translocation to PtdInsP(2)-Enriched Membranes
por: Casas, Javier, et al.
Publicado: (2022)

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis
por: Xian, Xunde, et al.
Publicado: (2017)

Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia
por: Pharaoh, Gavin, et al.
Publicado: (2020)

Cellular Cholesterol Distribution Influences Proteolytic Release of the LRP-1 Ectodomain
por: Dekky, Bassil, et al.
Publicado: (2016)

cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury
por: Li, Yun, et al.
Publicado: (2019)

Long-Term Lithium Treatment Increases cPLA(2) and iPLA(2) Activity in Cultured Cortical and Hippocampal Neurons
por: De-Paula, Vanessa de Jesus, et al.
Publicado: (2015)

Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson’s Disease
por: Paul, Sangita, et al.
Publicado: (2022)

Epidural Dexamethasone Decreased Inflammatory Hyperalgesia and Spinal cPLA(2) Expression in a Rat Formalin Test
por: Min, Sam-Hong, et al.
Publicado: (2014)

Inhibition of sPLA(2)-IIA Prevents LPS-Induced Neuroinflammation by Suppressing ERK1/2-cPLA(2)α Pathway in Mice Cerebral Cortex
por: Xiang, Yanxiao, et al.
Publicado: (2013)

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))
por: Psarra, Anastasia, et al.
Publicado: (2018)

Antiplatelet Effect of Daphnetin Is Regulated by cPLA(2)-Mediated Thromboxane A(2) Generation in Mice
por: Chaudhary, Preeti Kumari, et al.
Publicado: (2023)

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
por: Zhang, Haojie, et al.
Publicado: (2023)

Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression
por: Chang, Chao-Chien, et al.
Publicado: (2019)

Correction to “Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))”
por: Psarra, Anastasia, et al.
Publicado: (2019)

Detection and Differentiation of Breast Cancer Sub-Types using a cPLA2α Activatable Fluorophore
por: Chiorazzo, Michael G., et al.
Publicado: (2019)

Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia
por: Chang, Jia-Feng, et al.
Publicado: (2019)

PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
por: Sarkar, Chinmoy, et al.
Publicado: (2019)

The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
por: Aller, Stephen G., et al.
Publicado: (2022)

Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway
por: Xu, Shuo, et al.
Publicado: (2023)

Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors
por: Hussein, Mohammed Abdalla, et al.
Publicado: (2023)

Inhibition of Cytosolic Phospholipase A(2)α (cPLA(2)α) by Medicinal Plants in Relation to Their Phenolic Content
por: Arnold, Eva, et al.
Publicado: (2015)

The effects of myelin on macrophage activation are phenotypic specific via cPLA(2) in the context of spinal cord injury inflammation
por: Kopper, Timothy J., et al.
Publicado: (2021)

cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment
por: Mishra, Sanjay, et al.
Publicado: (2022)

Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA(2)α/COX-1 Pathway
por: Astudillo, Alma M., et al.
Publicado: (2021)

CPLA 1.0: an integrated database of protein lysine acetylation
por: Liu, Zexian, et al.
Publicado: (2011)

Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo
por: Dietrich, Martin F., et al.
Publicado: (2010)

HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer
por: Pan, Penglin, et al.
Publicado: (2022)

Leptin Promotes cPLA(2) Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade
por: Hsu, Pei-Sung, et al.
Publicado: (2015)

Phosphatidylcholine-Mediated Aqueous Diffusion of Cellular Cholesterol Down-Regulates the ABCA1 Transporter in Human Skin Fibroblasts
por: Akopian, David, et al.
Publicado: (2015)

PPAR Activation Induces M1 Macrophage Polarization via cPLA(2)-COX-2 Inhibition, Activating ROS Production against Leishmania mexicana
por: Díaz-Gandarilla, J. A., et al.
Publicado: (2013)

Dapagliflozin Reduces Apoptosis of Diabetic Retina and Human Retinal Microvascular Endothelial Cells Through ERK1/2/cPLA2/AA/ROS Pathway Independent of Hypoglycemic
por: Hu, Yuxin, et al.
Publicado: (2022)

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
por: Choi, Hong Y., et al.
Publicado: (2009)

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
por: Gynther, Mikko, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_664ad4kuectqhfeg54r9pc8246